Learn Tech

CAREER: Elucidating the Targets and Functions of Mammalian tRNA methyltransferase orthologs: University of Rochester

Dragony Fu

[email protected]

The goal of this research is to understand how ribonucleic acid (RNA) molecules influence cell growth, development, and response to the environment. Current evidence shows that RNA function can be regulated by the presence of chemical groups (modifications) that are added to the RNA by specific enzymes. However, much remains to be learned about how the enzymes find their target RNAs, how the modifications change RNA functions, and how the modified RNAs regulate critical cellular processes. This research will address those questions, while providing a dynamic research environment to foster the scientific training and development of underrepresented groups in science such as minorities and women. To share new technical approaches developed during the research, students will produce video-based tutorials to serve as a teaching and training resource for the scientific community. The project will also provide educational workshops for underserved high school students to encourage curiosity and experimentation in the field of biology. <br/><br/>Mammalian genomes are predicted to encode a diverse number of transfer RNA methyltransferase (Trm) enzymes, but the cellular functions for the majority of Trm proteins remain unknown. The following project aims to elucidate the biological roles of the numerous uncharacterized mammalian Trm enzymes by: 1) establishing the protein interaction networks of human Trm enzymes, 2) identifying the cellular targets of Trm proteins, and 3) determining the cellular processes modulated by Trm proteins. The goals will be achieved through an integrated biochemical, molecular and genetic approach involving proteomic analysis of Trm complexes together with global transcription and translation profiling of human cells with altered Trm proteins. Through these discoveries, the work promises to lay a foundation of new understanding of how the RNA modifications catalyzed by diverse Trm enzymes translate into physiological outputs that help cells respond to various environmental conditions.

About Exponent

Exponent is a modern business theme, that lets you build stunning high performance websites using a fully visual interface. Start with any of the demos below or build one on your own.

Get Started

Leave a Reply

Your email address will not be published. Required fields are marked *

Privacy Settings
We use cookies to enhance your experience while using our website. If you are using our Services via a browser you can restrict, block or remove cookies through your web browser settings. We also use content and scripts from third parties that may use tracking technologies. You can selectively provide your consent below to allow such third party embeds. For complete information about the cookies we use, data we collect and how we process them, please check our Privacy Policy
Youtube
Consent to display content from Youtube
Vimeo
Consent to display content from Vimeo
Google Maps
Consent to display content from Google
Spotify
Consent to display content from Spotify
Sound Cloud
Consent to display content from Sound